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In this review, we summarized information about the ABC gene families in aquatic invertebrates, considering their evolution and putative functions in defense mechanisms. As this superfamily is derived from a common ancestor, ABC genes have evolved via lineage-specific duplications through the process of adaptation. The ABC proteins function as active transporters for multiple substrates across the cellular membrane by ATP hydrolysis. The ATP-binding cassette ( ABC) protein superfamily is known to play a fundamental role in biological processes and is highly conserved across animal taxa. Jeong, Chang-Bum Kim, Hui-Su Kang, Hye-Min Lee, Jae-Seong New structural and biochemical information from prokaryotic ABC proteins and functional information from CFTR channels has led to a unifying mechanism explaining those ATP-driven conformational changes.ДЄTP-binding cassette ( ABC) proteins in aquatic invertebrates: Evolutionary significance and application in marine ecotoxicology. ATP-driven conformational changes, which in other ABC proteins fuel uphill substrate transport across cellular membranes, in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient. These channels belong to the superfamily of ABC transporter ATPases. Vergani, Paola CsanГѓВЎdy, LГѓВЎszlГѓВіД¬FTR chloride channels are encoded by the gene mutated in patients with cystic fibrosis. Go to Extra, Options, and then tab performance to extend the netwerkbuffer to 15 seconds.The ABC protein turned chloride channel whose failure causes cystic fibrosis

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